Thermo Kit PCP Rgt DRI

Specifications

• Control Sets: MGC Multi-Drug Controls
• Description: DRI Phencyclidine (PCP) Drugs of Abuse Assay for Indiko
• Detectable Analytes: Phencyclidine
• DoA Calibrators: DRI Multi-Drug Calibrators
• Quantity: 3 x 18mL
• Storage Requirements: 2° to 8°C
  

Intended Use

The DRI® Phencyclidine Assay is intended for the qualitative and semi-quantitative determination of phencyclidine in human urine.

Summary and Explanation of the Test

Phencyclidine (PCP) was originally made available as a surgical anesthetic agent, but it was removed from clinical use due to undesirable side effects both during surgery and in recovery. The illicit use of the drug produces clinical symptoms ranging from confusion, disorientation, stupor, coma and death in cases of overdose.

The DRI Phencyclidine Assay is a homogeneous enzyme immunoassay using ready-to-use liquid reagents. The assay is based on the competition of a drug labeled with enzyme, glucose-6-phosphate dehydrogenase (G6PDH), and the drug from the urine sample for a fixed amount of specific antibody binding sites. In the absence of drug from the sample, the specific antibody binds the drug labeled with G6PDH and the enzyme activity is inhibited. This phenomenon creates a direct relationship between the drug concentration in urine and the enzyme activity. The G6PDH activity is determined spectrophotometrically at 340 nm by measuring its ability to convert nicotinamide adenine dinucleotide (NAD) to NADH.